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A recent study suggests that a particular genetic variant in humans, associated with insulin release, may contribute to increased resistance to obesity.
This variant exhibits distinct behavior in cells, potentially resulting in a more efficient metabolic process.
Let's find out more about how it might work.
The study reveals how genetic variations impact weight gain susceptibility.
Approximately 20 percent of people of European descent have just one copy of this variant, while around 5 percent tend to have two copies.
The variant affects the interaction between the GIP receptor and a hormone released after eating.
The lucky individuals with this variant may have a metabolism that reduces obesity risk.
In cells, the variant led to increased insulin production in response to glucose and the GIP hormone, potentially explaining improved glucose processing.
Further experiments are needed to confirm the effects of this variant on receptor behavior and its impact on other cell types involved in hunger regulation.
Understanding how individuals with different genetic variants in the GIP receptor respond to existing weight loss medications is crucial.
This knowledge could support a personalized approach to weight loss by matching specific drugs to genetic variants.
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