Scientists discovered that a protein called phosphorylated -synuclein, which is associated with diseases like Parkinson's and Lewy body dementia, also has a role in how the brain communicates normally.
When a phosphate ion is added to -synuclein, it changes the way the protein looks and behaves.
Let's find out how it was discovered.
It's not like we used to think
Previous studies focused on phosphorylated -synuclein in disease states, assuming it to be a marker of pathology.
However, this research challenges that assumption and suggests -synuclein phosphorylation may be necessary for its normal function in healthy brains.
Phosphorylated -synuclein helps control how neurons send signals and interacts with other proteins.
When there is more neural activity, there tends to be more phosphorylated -synuclein, suggesting a possible link between synaptic activity and phosphorylation.
Phosphorylated -synuclein helps organize a group of proteins that regulate synaptic vesicles and reduce neuronal activity.
This means that phosphorylated -synuclein acts like a brake in certain circuits of the brain.
Why it's important
The findings highlight the significance of -synuclein phosphorylation in healthy brains.
Also, it shows the need for further research to understand its role in disease development and the potential unintended consequences of blocking phosphorylation.
Previously, we talked about the dangers of hearing loss.
