Memory formation can be different: A new study

Have you ever wondered why you can't remember some things even if you try hard to do it?

It turns out that there are two parallel types of remembering things, and they work differently.

Let's find out more about the discovery that proves it.

What they've discovered

Researchers at Tohoku University have discovered that memory formation involves two distinct processes happening in parallel when mice learn new motor skills. 

The first, called "online learning," occurs during active training, while the second, known as "offline learning," happens during rest after training.

Manipulating glial cell activity can enhance or reduce online learning, but offline learning remains unaffected. 

Glial cells, once thought to fill gaps between neurons, play an active role by releasing signaling molecules like glutamate.

The study used a task where mice tracked a moving visual stimulus with their eyes. 

During training, mice showed online learning, and during a subsequent resting period, they demonstrated offline learning.

Genetically manipulating glial cells revealed their role. Increasing glutamate release enhanced online learning, but the effect was temporary. 

Inhibiting glial activity suppressed online learning, but offline learning persisted. 

Why it's important

This research suggests memory formation is parallel and independent, not a single, sequential process. 

It highlights the crucial role of glial cells in modulating synaptic plasticity during both online and offline learning, potentially offering insights for interventions in memory-related conditions.
 

• Related news:
• research
• memory
• brain
• learning
• 6 November 2023

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