Why men and women might need different meds: How male and female cells respond to stress

Have you ever wondered whether men and women actually need different meds for better results?

Scientific excellence demands diversity, but many life sciences studies solely use male mice, overlooking gender variations. 

In fact, it might be a problem, because a new study shows that brain cells of male and female mice respond differently.

A study on stress and gender

A Weizmann Institute of Science study delved into stress responses, revealing gender-specific differences in brain cells of mice. 

These variations could impact disorders triggered by chronic stress, like anxiety, depression, obesity, and diabetes, potentially leading to personalized therapies.

Chronic stress-related mental and physical issues are on the rise, affecting genders uniquely. 

By scrutinizing brain responses on a cellular level, researchers uncovered a key distinction: male mice's stress-altered gene expressions and cell structures, while female mice remained unaffected. 

This emphasizes the necessity of considering gender disparities in stress-related health conditions.

Why is it important?

Historically, clinical trials favored males, disregarding gender's role. 

Similarly, preclinical studies often omitted female animals. 

However, understanding gender impacts is vital. 

The study underscores the significance of diversity and sensitive research methods, promoting a comprehensive grasp of stress-related health conditions. 
 

• Related news:
• research
• stress
• brain
• 12 August 2023

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