Scientists in Japan discovered that a special kind of brain cell, called kisspeptin neurons, has an important job in controlling hormones related to female reproduction, like making eggs and releasing them.
These neurons are crucial for processes like the development of egg follicles and ovulation.
Let's find out more about the discovery.
How it was discovered
The research looked at two parts of the brain: the arcuate nucleus (ARC) and the anteroventral periventricular nucleus (AVPV).
In these areas, special cells called kisspeptin neurons were found to produce and respond to a substance called dynorphin, which slows things down.
To understand the role of these neurons, scientists changed the genes of female rats to remove the part responsible for kisspeptin in neurons with dynorphin receptors.
These rats, although still able to have babies, showed changes in their reproductive functions.
They had a longer cycle of fertility, their ovaries weighed less, and they had fewer baby rats compared to normal rats.
The study suggests that kisspeptin neurons with dynorphin receptors are really important for the usual reproduction process in female rats.
They affect how hormones are released and when eggs are released.
Why it's important
The findings could aid in understanding and treating various reproductive disorders in animals and humans, providing insights into the molecular mechanisms controlling kisspeptin neuronal activity.
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