Chronic stress activates depression: A new study on neurons and stress

A new study explores how chronic stress can affect our behavior and lead to problems like depression and reduced interest in things we usually enjoy. 

The researchers focused on a group of neurons in the brain called proopiomelanocortin (POMC) neurons.

Let's look at the most important parts of the research.

Hyperactive Neurons

After exposing mice to chronic stress for ten days, the POMC neurons in their brains became hyperactive. 

These neurons are found in the hypothalamus, a part of the brain that controls various functions like hormones, hunger, and mood.

Negative Behavioral Changes

When these POMC neurons became hyperactive, it resulted in behavioral changes in the mice, such as anhedonia and signs of depression.

In humans, anhedonia might mean losing interest in friends and a reduced sex drive.

Inhibition Reduces Behavioral Changes

When the scientists reduced the activity of these hyperactive POMC neurons, it lessened the behavioral changes brought on by stress.

Intrinsic Mechanism

The researchers suspect that an intrinsic mechanism, possibly involving potassium channels in the POMC neurons, plays a significant role in making these neurons hyperactive due to chronic stress.

Potential Treatment

Opening these potassium channels, which can decrease excessive neural firing, might be a potential treatment for restraining hyperactive POMC neurons.

Conclusion

Understanding how stress affects these neurons provides insights into the link between stress and mood disorders like depression. 

It also offers potential avenues for developing treatments to help people dealing with chronic stress and its consequences.
 

• Related news:
• research
• stress
• depression
• brain
• 15 October 2023

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