Researching treatment-resistant depression: A new study

Modern science knows that genes can play a huge role in many psychological and mental conditions, including depression.

A team of scientists researched the genes that might be involved in treatment-resistant depression.

Here's what they've found.

How it was researched

In the latest experiment, scientists looked at how a gene interacts with stress to contribute to treatment-resistant major depressive disorder (MDD) in animals.

Using a mouse model of depression caused by chronic social defeat stress, they focused on a gene called LHPP that affects brain signaling.

They discovered that when the stressed mice had increased levels of LHPP, their depression-like behaviors became significantly worse.

Also, in people, mutations in the LHPP gene might have an antidepressant effect.

Treatment-resistant type of depression is a subtype of MDD where standard antidepressant meds don't work effectively.

The experiment also discovered that esketamine, a different medication, was successful in reducing depression-like behaviors induced by LHPP.

Why it's important

These facts provide valuable facts into the complicated relationship between factors like genetics, stress, and treatment-resistant depression.

This research helps us understand the biology behind treatment-resistant forms of depression and may lead to new treatments in the future.
 

• Related news:
• research
• depression
• meds
• brain
• 19 November 2023

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