Peripheral neuropathy affects over 3 million people in the US annually, causing pain and loss of feeling.
Scientists have discovered a mechanism that can effectively heal damaged nerves in lab mice.
Their experiment highlights that a protein called Mitf activates the specific repair function of Schwann cells in the peripheral nervous system.
How it was discovered
New research offers hope for developing treatments for peripheral neuropathy.
The study focused on Schwann cells, and their goal is to protect and support neurons' axons.
Interestingly, the peripheral nervous system has a remarkable ability to repair itself, unlike the central nervous system.
Using mouse models of Charcot Marie Tooth disease, the scientists discovered that a specific protein called Mitf plays a vital role in repairing this nerve damage.
Mitf responds to damage by moving from the cytoplasm to the nucleus of Schwann cells. This prompts the cells to effectively initiate repairs.
When Mitf was removed, nerve repair was halted, highlighting its importance. Exploiting Schwann cell repair programs may hold promise for treating chronic diseases.
The scientists plan to further investigate diabetic neuropathy and explore therapeutic approaches that enhance the repair pathway.
