Modern science knows that genes can play a huge role in many psychological and mental conditions, including depression.
A team of scientists researched the genes that might be involved in treatment-resistant depression.
Here's what they've found.
How it was researched
In the latest experiment, scientists looked at how a gene interacts with stress to contribute to treatment-resistant major depressive disorder (MDD) in animals.
Using a mouse model of depression caused by chronic social defeat stress, they focused on a gene called LHPP that affects brain signaling.
They discovered that when the stressed mice had increased levels of LHPP, their depression-like behaviors became significantly worse.
Also, in people, mutations in the LHPP gene might have an antidepressant effect.
Treatment-resistant type of depression is a subtype of MDD where standard antidepressant meds don't work effectively.
The experiment also discovered that esketamine, a different medication, was successful in reducing depression-like behaviors induced by LHPP.
Why it's important
These facts provide valuable facts into the complicated relationship between factors like genetics, stress, and treatment-resistant depression.
This research helps us understand the biology behind treatment-resistant forms of depression and may lead to new treatments in the future.
